Vaccine Potency and Structure of Yeast-Produced Polio Type 2 Stabilized Virus-like Particles
Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines.Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for the impending polio-free era.In this study, we investigate the production, antigenicity, thermostabili